In 2025, the CLI Global Society made real progress toward our mission: preventing amputations and saving lives by improving how Critical Limb Ischemia (CLI) is recognized and treated worldwide. CLI is one of the most serious and under-recognized vascular conditions — when blood flow to the legs and feet becomes severely blocked, patients face a high risk of losing a limb, or their life, if the disease isn’t caught and treated in time.

This year, the Society continued to grow its global community of physicians, surgeons, and allied health professionals dedicated to improving CLI care, expanding its reach across new regions and specialties. We advanced education through conferences, training sessions, and clinical resources designed to help physicians identify CLI earlier and choose the most effective treatment path for their patients.

We also strengthened our commitment to research, supporting studies and data initiatives that build the evidence base for better, more consistent CLI care around the world. Alongside this, we expanded outreach and awareness efforts aimed at helping patients and the public recognize the warning signs of CLI — because early recognition is often the difference between saving a limb and losing one.

Partnerships with other medical societies, health systems, and advocacy groups helped extend our impact beyond our own membership, reinforcing that preventing amputation is a shared responsibility across the healthcare community.

None of this would be possible without the dedication of our members, volunteers, and partners. As we look ahead, the CLI Global Society remains focused on our founding purpose: making sure every patient with Critical Limb Ischemia has the best possible chance to keep their limb — and their life.